Together they have synergistic effects that make them useful in the prevention and early at-home treatment of COVID-19.
STORY AT-A-GLANCE
- Vitamin C and quercetin have synergistic effects that make them useful in the prevention and early at-home treatment of COVID-19. Both are part of the MATH+ protocol developed by the Front Line COVID-19 Critical Care Working Group (FLCCC)
- For COVID-19 prophylaxis, the FLCCC recommends vitamin C, quercetin, zinc, melatonin and vitamin D3
- The at-home treatment for mildly symptomatic patients is very similar to the prophylactic regimen, but adds several optional drugs, including aspirin, famotidine (an antacid) and ivermectin (a heartworm medication that has been shown to inhibit SARS-CoV-2 replication in vitro)
- The in-hospital MATH+ protocol calls for intravenous methylprednisolone, high-dose ascorbic acid (vitamin C), thiamine and heparin. Optional additions include melatonin, zinc, vitamin D3, atorvastatin, famotidine and magnesium
- There are two distinct phases or stages of COVID-19 — the viral replication stage and the immune dysfunction stage — and the treatment must be appropriate for the stage you’re in. Equally crucial is starting aggressive treatment as early as possible

Quercetin was initially found to provide broad-spectrum protection against SARS coronavirus in the aftermath of the SARS epidemic that broke out across 26 countries in 2003.1Journal of Virology Sep 2004, 78 (20) 11334-11339, Antiviral activity of an analog of luteolin2Bioorg Med Chem. 2006 Dec 15;14(24):8295-3063Maclean’s February 24, 2020 Now, some doctors are advocating its use against SARS-CoV-2, in combination with vitamin C, noting that the two have synergistic effects.
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